Gastro-Intestinal Stromal Tumours

Gastro-Intestinal Stromal Tumours

Gastrointestinal stromal tumours (GIST) affect the connective and supportive tissues of the digestive tract or nearby structures within the abdomen. They are a rare cancer, accounting for approximately 2% of tumours in the gastrointestinal region and are highly resistant to chemotherapy. In many cases the cause is found to be activating mutations in the cKIT and PDGFRA genes. Clinical evidence demonstrates that mutation status can predict the patient response to tyrosine kinase inhibitors such as Imatinib.

Therefore, the identification of the genotype of the tumour can be used to confirm diagnosis, determine the appropriate treatment response and provide prognostic information.

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NewGene Limited | Company Number: 06735445

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